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Recombinant Human Vascular Endothelial Growth Factor 165 (VEGF-165)
Price range: $200.00 through $4,500.00
Vascular Endothelial Growth Factor 165 (VEGF 165) is a major isoform of the VEGF-A family and a key mediator of angiogenesis, vasculogenesis, and endothelial cell function. It exerts its biological activity by binding to VEGF receptors (VEGFR-1 and VEGFR-2) in the presence of co-receptors such as neuropilin-1, initiating downstream signaling cascades including the MAPK, PI3K/AKT, and PLCγ pathways. These pathways regulate endothelial cell proliferation, migration, survival, and new blood vessel formation.
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Product Specifications
| Storage | -20°C |
|---|---|
| Storage Information | Avoid freeze/thaw cycles |
| Species | Human |
| Amino Acid Sequence | APMAEGGGQN HHEVVKFMDV YQRSYCHPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCGGC CNDEGLECVP TEESNITMQI MRIKPHQGQH IGEMSFLQHN KCECRPKKDR ARQENPCGPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR |
| Molecular Weight | 19.2 kDa (Expected) |
| Class | Recombinant |
| Purity | > 95% by SDS-PAGE gel |
| Endotoxin Concentration | < 1 EU/µg |
| Biologically Active | Yes |
| Biological Activity | The biological activity is confirmed by its ability to stimulate the proliferation of human umbilical vein endothelial cells (HUVECs). |
| Form | Lyophilized |
| Shipping Conditions | Ambient |
| Reconstitution | Reconstitute with 10 mM Sodium Citrate, pH 6.0+ 0.1% BSA |
Applications
- Endothelial cell proliferation and migration assays
- Angiogenesis studies in vitro and in vivo, including tube formation and sprouting models
- Vasculogenesis and vascular remodeling during development and regeneration
- Wound healing and tissue repair research
- Cancer biology, including tumor angiogenesis and metastasis models
- Hypoxia response and ischemia models for cardiovascular research
- Tissue engineering and biomaterial vascularization
- Retinal and ocular disease studies involving neovascularization
