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Design. Build. Deliver. Advanced Biologics.
Rethinking the future of research & therapeutics
We are a Biotechnology Company Specializing in Custom Biologics Design and Manufacturing
Welcome to ORF Biologics, Inc., where innovation meets excellence in the field of biotechnology. Located in Tiffin, Iowa, our specialty is pioneering next-generation biologics for research and therapeutic applications. With over 45 years of industry experience, we deliver cutting-edge technologies that empower pharmaceutical and biotech companies, helping them accelerate their discoveries and development processes.
Critical Biologics Capabilities
We engineer proteins that are hard to make, easy to scale, and critically needed—especially in fields like infectious disease, neurodegeneration, regenerative medicine, and biosecurity. Our work is guided by speed, scientific precision, and a commitment to doing world-class science in Iowa.
Development
Manufacturing
Testing
Quality Control System
We offer a comprehensive biologics development process, from designing proteins using synthetic biology to expression, purification, and final delivery. Our integrated workflow ensures the production of high-quality, tailored proteins for specific applications.
We specialize in plasmid manufacturing, genetic engineering, and clone optimization for biologic production. Our process includes scalable protein expression to ensure consistent, high-yield results for research applications.
Our biologics testing includes real-time in-process sampling, final product evaluation, and stability testing to ensure protein integrity, functionality, and long-term viability for research and animal model applications applications.
Our quality control system ensures biologic integrity at every stage of development through rigorous testing protocols. This proactive approach helps identify and resolve potential issues early, ensuring consistency and accuracy throughout the process.
Products
Relentlessly Innovative
Our lean, self-sufficient model supports quick turnaround for recombinant proteins, pilot batches, and R&D-grade materials with GMP-aware design principles.
Off The Shelf Biologics
Our modular and flexible production systems deliver ready-to-use biologics with consistent performance, rapid availability, and scalable supply that accelerate research timelines and deliver results at every stage.
Custom Biologics
We specialize in creating custom biologic products, tailored to meet the specific needs of your research or therapeutic applications, ensuring precision, functionality and innovation.
View All Products
Explore our complete range of biologic products designed for various applications, from neuroscience to therapeutic development, all crafted with the highest standards of quality.
Scientific Advisory Board
Mission-Driven Science
We exist to fill high-value gaps that others overlook: to deliver biologics faster, smarter, and closer to home. Whether it’s pandemic response, neurorepair, or therapeutic protein engineering, ORF Biologics stands ready to deliver industrial-grade solutions at biotech speed.
Expert-led innovation
Our advisory board brings together industry-leading scientists to guide advancements in synthetic biology and protein engineering.
Cutting-Edge Research
With deep expertise across biotechnology, our advisors help shape groundbreaking solutions for drug discovery and biologic development.
Strategic Guidance
We leverage scientific insight to refine processes, optimize workflows, and accelerate the path from concept to prototype.
Innovation Partners
Advancing Science, Together
From early-stage research to process development, we partner with precision researchers, biotech innovators, and pharmaceutical leaders to engineer custom proteins and refine synthetic biology workflows.
Precision Researchers
Those requiring high-purity, stand-alone proteins for specialized applications such as assay development, structural studies, or proof-of-concept research. They prioritize consistency, quality, and bioactivity, ensuring that the protein performs reliably in their experiments.
Scalable Innovators
Biotech startups, diagnostics companies, and researchers who need proteins or biologics on a recurring basis to support their ongoing projects or product pipelines. They seek scalable production solutions, reliable supply chains, and customizable formulations to ensure long-term success.
Pharma Leaders
Pharmaceutical companies and biotech innovators require custom protein engineering and synthetic biology solutions to develop novel therapeutics. They focus on prototype development, early-stage process optimization, and proof-of-concept studies to refine their biologic candidates.
Latest News
We’re continuously pushing the boundaries of synthetic biology and protein production, driving new solutions for research and therapeutics. Stay tuned for our latest advancements!
News
We offer dedicated scientific support to educate, troubleshoot, and collaborate with researchers advancing biologics.
Events
We are a thriving community united by a common purpose: empowering scientists to drive biologics research forward.
New Products
Explore our latest innovations in biologics—designed to accelerate discovery and support your next breakthrough.