Your cart is currently empty!
Recombinant Human Receptor Activator of Nuclear Factor-kB Ligand (RANKL)
Price range: $200.00 through $5,000.00
Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) is a key member of the tumor necrosis factor (TNF) superfamily, known for its critical role in regulating cell differentiation, proliferation, and survival. RANKL exists as a type II homotrimeric transmembrane protein and can be found in both membrane-bound and soluble forms.
Show More
Product Specifications
| Storage Information | Avoid freeze/thaw cycles |
|---|---|
| Species | Human |
| Amino Acid Sequence | EKAMVDGSWL DLAKRSKLEA QPFAHLTINA TDIPSGSHKV SLSSWYHDRG WAKISNMTFS NGKLIVNQDG FYYLYANICF RHHETSGDLA TEYLQLMVYV TKTSIKIPSS HTLMKGGSTK YWSGNSEFHF YSINVGGFFK LRSGEEISIE VSNPSLLDPD QDATYFGAFK VRDID |
| Molecular Weight | 19.7 kDa (Expected) |
| Class | Recombinant |
| Purity | > 95% by SDS-PAGE gel |
| Endotoxin Concentration | < 1 EU/ug |
| Biologically Active | Yes |
| Biological Activity | The activity of RANKL is determined by its dose-dependent ability to induce reporter gene in HT-29 NF-ÎşB Luc reporter cells. |
| Form | Lyophilized |
| Shipping Conditions | Ambient |
| Reconstitution | Reconstitute with sterile PBS. |
| Storage Temperature | -20°C |
Applications
- Osteoclast Differentiation – Induces osteoclast formation and activity from precursor cells in vitro
- Bone Metabolism Research – Supports studies of bone remodeling, osteoporosis, and related disorders
- Immune Regulation – Enables investigation of RANKL-mediated T cell activation and dendritic cell survival
