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Recombinant Human Receptor Activator of Nuclear Factor-kB Ligand, His Tag (RANKL, His Tag)
Price range: $175.00 through $4,000.00
Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) is a key TNF superfamily cytokine essential for osteoclast differentiation, bone remodeling, and immune regulation. RANKL functions as a soluble or membrane-associated homotrimer that binds the RANK receptor to activate downstream pathways, including AKT-mediated survival signaling. Its activity is naturally modulated by the decoy receptor OPG.
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Product Specifications
| Storage | -20°C |
|---|---|
| Storage Information | Avoid freeze/thaw cycles |
| Species | Human |
| Amino Acid Sequence | EKAMVDGSWL DLAKRSKLEA QPFAHLTINA TDIPSGSHKV SLSSWYHDRG WAKISNMTFS NGKLIVNQDG FYYLYANICF RHHETSGDLA TEYLQLMVYV TKTSIKIPSS HTLMKGGSTK YWSGNSEFHF YSINVGGFFK LRSGEEISIE VSNPSLLDPD QDATYFGAFK VRDIDHHHHH H |
| Molecular Weight | 20.4 kDa (Expected) |
| Class | Recombinant |
| Purity | > 95% by SDS-PAGE gel |
| Endotoxin Concentration | < 1 EU/ug |
| Biologically Active | Yes |
| Biological Activity | The activity of RANKL is determined by its dose-dependent ability to induce reporter gene in HT-29 NF-κB Luc reporter cells. |
| Form | Lyophilized |
| Shipping Conditions | Ambient |
| Reconstitution | Reconstitute with sterile PBS. |
Applications
- Osteoclast Differentiation Assays: Supports in-vitro induction, maturation, and functional analysis of osteoclasts from primary cells or cell lines
- RANK–RANKL Signaling Studies: Enables investigation of downstream pathways such as NF-KB, AKT, and MAPK in bone, immune, and cancer biology models
- Protein–Protein Interaction and Binding Assays: Ideal for studying interactions with RANK or OPG using ELISA, BLI/SPR, pull-down assays, or Ni-NTA–based immobilization
- Immune Cell Activation and Differentiation Models: Facilitates research on T cell activation, dendritic cell function, lymph node development, and broader TNF superfamily signaling
