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Recombinant Human Platelet Derived Growth Factor BB (PDGF-BB)
Price range: $200.00 through $4,500.00
Platelet-Derived Growth Factor-BB (PDGF-BB) is a biologically active homodimeric isoform of the PDGF family, playing a critical role in cell proliferation, migration, and tissue repair. It functions by binding to PDGF receptors (PDGFR-α and PDGFR-β), triggering receptor dimerization and activation of downstream signaling pathways such as MAPK, PI3K/AKT, and JAK/STAT. These pathways regulate the behavior of mesenchymal cells, smooth muscle cells, fibroblasts, and pericytes, contributing to processes like angiogenesis, wound healing, and tissue remodeling.
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Product Specifications
| Storage | -20°C |
|---|---|
| Storage Information | Avoid freeze/thaw cycles |
| Species | Human |
| Amino Acid Sequence | SLGSLTIAEP AMIAECKTRT EVFEISRRLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RPTQVQLRPV QVRKIEIVRK KPIFKKATVT LEDHLACKCE TVAAARPVT |
| Molecular Weight | 12.3 kDa (Expected) |
| Class | Recombinant |
| Purity | > 95% by SDS-PAGE gel |
| Endotoxin Concentration | < 1 EU/µg |
| Biologically Active | Yes |
| Biological Activity | The biological activity is confirmed by the stimulation of Balb/c 3T3 cells. |
| Form | Lyophilized |
| Shipping Conditions | Ambient |
| Reconstitution | Reconstitute with PBS + 0.1% BSA |
Applications
- Mesenchymal cell proliferation and migration studies
- Fibroblast activation and extracellular matrix production
- Angiogenesis and vascular stabilization research
- Wound healing and tissue regeneration models
- Smooth muscle cell biology and vascular remodeling studies
- Pericyte recruitment and vessel maturation in co-culture systems
- Fibrosis modeling in liver, lung, kidney, and cardiac tissues
- Cancer research, including tumor stroma interactions and PDGF signaling
- Tissue engineering and biomaterial integration studies
