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HN Shell 400 Resin
$385.00
HN Shell 400 is engineered using core–shell technology combined with multi-modal ligand functionality, integrating size exclusion, hydrophobic interaction, and ion exchange within a single medium. Designed for the purification of very large biomolecules (>400 kDa), the rigid particle architecture supports high flow rates and excellent resolution.
Product Specifications
| Catalog Number | ORF.HNSHELL400 |
|---|---|
| Storage Solutions | 20% ethanol |
| Matrix | Highly crosslinked agarose core with functionalized polymeric shell |
| Ligand | Multi-modal (hydrophobic + ionic functional groups) |
| Particle Size | 80–120 µm |
| Dynamic Binding Capacity | Not applicable (size-exclusion resin) |
| pH Stability Operation | 3–12 |
| pH Stability Cleaning | 2–13 (short-term) |
| Cleaning/CIP | 0.1–0.5 M NaOH or 20% ethanol |
| Flow Rate | <600 cm/h |
| Chemical Stability | Compatible with NaOH ≤0.5 M, salts, mild detergents, 20% ethanol |
| Mode of Action | Size exclusion–dominant with HIC/IEX contributions |
| SBC | 2000 L |
| APC | 200,000 L |
| Application | Purification of biomolecules >400 kDa |
| Operating Pressure | <0.5 MPa |
Applications
- Separation and purification of biomolecules larger than 400 kDa
- Suitable for viral particles, large protein complexes, polysaccharide conjugates
- Ideal for polishing steps requiring controlled size-exclusion behavior with multi-modal selectivity
- Supports preparative and process-scale workflows
