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Recombinant Human Fibroblast Growth Factor Basic (FGF-2)
$100.00 – $1,000.00
Fibroblast Growth Factor 2 (FGF-2), also known as basic FGF, is a potent mitogenic and angiogenic cytokine that plays a crucial role in cell proliferation, survival, and differentiation across various tissue types. It exerts its biological effects by binding to FGF receptors (FGFRs) in the presence of heparan sulfate proteoglycans, activating downstream signaling pathways such as MAPK, PI3K/AKT, and PLCγ. These pathways regulate diverse cellular processes including stem cell self-renewal, neurogenesis, and vascular development.
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Product Specifications
| Storage | -20°C |
|---|---|
| Storage Information | Avoid freeze/thaw cycles |
| Species | Human |
| Amino Acid Sequence | AAGSITTLPA LPEDGGSGAF PPGHFKDPKR LYCKNGGFFL RIHPDGRVDG VREKSDPHIK LQLQAEERGV VSIKGVCANR YLAMKEDGRL LASKCVTDEC FFFERLESNN YNTYRSRKYT SWYVALKRTG QYKLGSKTGP GQKAILFLPM SAKS |
| Molecular Weight | 17.1 kDa (Expected) |
| Class | Recombinant |
| Purity | > 95% by SDS-PAGE gel |
| Endotoxin Concentration | < 1 EU/µg |
| Biologically Active | Yes |
| Biological Activity | The biological activity is confirmed by a cell proliferation assay using Balb/c 3T3 cells. |
| Form | Lyophilized |
| Shipping Conditions | Ambient |
| Reconstitution | Reconstitute with PBS + 0.1% BSA |
Applications
- Maintenance and expansion of iPSCs in defined, feeder-free culture systems
- Pluripotent and multipotent stem cell proliferation, including hESCs and MSCs
- Neural stem cell growth and differentiation in developmental and disease models
- Angiogenesis and vascular biology research, including endothelial cell expansion
- Wound healing and tissue regeneration studies
- Cancer biology investigations, particularly in tumor growth and angiogenesis
- Mesodermal and ectodermal lineage specification in differentiation protocols
- Tissue engineering and biomaterial development for regenerative applications
