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Recombinant Human Brain-Derived Neurotrophic Factor (BDNF)
$200.00 – $5,500.00
Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family, essential for the development, survival, and plasticity of neurons in the central and peripheral nervous systems. It binds primarily to the TrkB receptor, triggering intracellular signaling cascades such as MAPK, PI3K, and PLCγ pathways, which regulate neuronal differentiation, synaptic growth, and long-term potentiation—key mechanisms underlying learning and memory.
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Product Specifications
| Catalog Number | BDNF |
|---|---|
| Storage | -20°C |
| Storage Information | Avoid freeze/thaw cycles |
| Species | Human |
| Amino Acid Sequence | H S D P A R R G E L S V C D S I S E W V T A A D K K T A V D M S G G T V T V L E K V P V S K G Q L K Q Y F Y E T K C N P M G Y T K E G C R G I D K R H W N S Q C R T T Q S Y V R A L T M D S K K R I G W R F I R I D T S C V C T L T I K R G R |
| Molecular Weight | 13.4 kDa (Expected) |
| Class | Recombinant |
| Purity | > 95% by SDS-PAGE gel |
| Endotoxin Concentration | < 1 EU/µg |
| Biologically Active | Yes |
| Biological Activity | The activity of BDNF is determined by its ability to stimulate TrkB receptor phosphorylation and downstream signaling in relevant cell models. Each lot is tested to ensure consistent neurotrophic activity in culture. |
| Form | Lyophilized |
| Shipping Conditions | Ambient |
| Reconstitution | Reconstitute with sterile PBS + 0.1% BSA |
Applications
- Neuronal differentiation and outgrowth assays
- Neural stem cell maintenance
- Neuroprotection in in vitro or in vivo models
- Screening of neuroactive compounds
- Research in neuroscience applications such as depression, Alzheimer’s disease, and TBI
